Publication: Bves: Ten years after
Authors
Hager, Hillari A. ; Bader, David M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Bves was discovered in 1999 by two
independent laboratories using screens to identify novel
genes that were highly expressed in the developing heart
(Reese et al., 1999; Andree et al., 2000). As an
evolutionarily conserved transmembrane protein, Bves is
postulated to play a role in cell adhesion and cell
motility. In studies of Bves protein disruption, there have
been multiple phenotypes, but few molecular
mechanisms have been advanced to explain the
underlying cause of these phenotypes. As the molecular
function of Bves protein begins to be uncovered, it is
now time to review the literature to examine the
significance of this work and future directions of study.
This review summarizes the literature on this unique
protein and explores new and exciting data that support
emerging themes on its molecular function.
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