Publication: Co-expression and prognostic value of gross cystic disease fluid protein 15 and mammaglobin in primary breast cancer
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Date
2007
Authors
Fritzsche, F.R. ; Thomas, A. ; Winzer, K.J. ; Beyer, B. ; Dankof, A. ; Bellach, J. ; Dahl, E. ; Dietel, Manfred ; Kristiansen, Gitte
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Gross cystic disease fluid protein (GCDFP-
15) and mammaglobin are both widely used and
accepted markers for epithelia of breast origin. We
aimed to evaluate their relation of expression on parallel
whole tissue sections in primary breast cancer by
immunohistochemistry and also to correlate it with
clinico-pathological parameters including patient
survival. Primary breast carcinomas from 165 patients
with a mean clinical follow-up of 73 months were
immunostained using commercially available antibodies
against GCDFP-15 and mammaglobin. An immunoreactive
score (IRS) was calculated based on the
cytoplasmic staining intensity and the number of cells
stained. Cytoplasmic expression of GCDFP-15 and
mammaglobin was observed in 73.3% and 72.1% of
invasive breast carcinomas respectively. 91.8% of breast
cancer cases expressed at least one of both markers.
Both markers strongly correlated with each other and
were significantly associated with lower tumour grading.
Additionally, GCDFP-15 negativity was significantly
associated with shortened disease-free survival times in
univariate and multivariate analyses. We demonstrated
the strong correlation of GCDFP-15 and mammaglobin
with each other and showed that only very few primary
breast cancers are completely negative for both markers.
The significantly longer disease free survival times for
patients with GCDFP-15 positive tumours clearly
warrants further study.
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