Publication: Ultrastructure of the area postrema of the monkey, Macaca fascic ularis
Authors
Ling, E. A. ; Wong, W.C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The area postrema of the monkey, Macaca
fascicularis, were a pair of oval organs at the caudal end
of the floor of fourth ventricle. Their ependymal lining was
covered by well-developed microvilli with occasional
overlying supraependymal cells. Two types of lining cells
were present: pyramidad- and flattened cells. The pyramidal
cell showed a long extending basal process resting on the
underlying blood vessels.
In transmission electron microscopy, the organ showed
numerous fenestrated sinusoids characterized by a distinct
perivascular space containing mast cells, macrophages and
collagen fibrils. The parenchyma of the organ was
composed of neurons and glial elements. Only one type of
neuron ranging from 9.5 to I5pm could be distinguished.
The neurons contained an indented nucleus surrounded by
organelle rich cytoplasm. The soma of the neuron was
enclosed by glial element resembling astrocyte. The glial
processes terminated on the blood vessel where they were
"tunnelled" by a variable number of nerve fibres some of
which gained a direct access to the externa1 basal lamina
of the perivascular space.
Synapses in the neuropil predominantly of the
axodendritic variety were observed. h o n terminals
containing round agranular vesicles were seen to make
synaptic contacts with the neurona1 soma. No structural
changes were observed in the area postrema following
bilateral cervical vagotomy. However, degenerating axon
terminals were observed in the subpostremal zone 7, 14 and
21 days after vagotomy suggesting a direct afferent
projection into this region.
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