Publication: Goodpasture's syndrome in ageing. An experimental study on the rat. I
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Date
1993
Authors
Escolar Castellón, J.de D. ; Mateos, J. ; Alfaro, E. ; Escolar, M.A. ; Miñana Amada, C. ; Roche, P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The following hypothesis is proposed:
Experimental lung disease in old rats is different
from this disease in adult rats. In order to demonstrate
this, we performed a morphometrical evaluation of the
pulmonary state of two groups of rats at different ages
and to which Goodpasture's syndrome had been induced.
115 Wistar rats were used. They were divided into
four different groups as follows: 1) Healthy adult rats
which had not been subjected to treatment; 2) diseased
adult rats to which antipulmonary serum had been
administered; 3) healthy old rats; and 4) diseased old
rats.
With the help of a computerized system, the length of
the alveolar chord, the thickness of the alveolar wall and
the surface of the bronchial-associated lymphoid tissue
in each group was calculated. We also counted the
number of alveolar macrophages (AM) with
haemosiderin, the percentage of goblet bronchial cells
and that of AM, lymphocytes and polymorphonuclear
leukocytes of the broncho-alveolar lavage (BAL).
The following results were obtained. When related to
the diseased adult rats, the diseased old rats showed an
increase in the alveolar chord and a decrease in the
thickness of the alveolar wall, as well as in the number
of AM with haemosiderin, globet cells and BAL lymphocytes.
These results support the proposed hypotheses, since
the diseased adult animals showed signs of alveolar
inflammation with interstitial edema, while in the
diseased old animals these results are compatible with
emphysema.
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