Publication: Increasing expression of fascin in renal cell carcinoma associated with clinicopathological parameters of aggressiveness
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Date
2006
Authors
Jin, J.S. ; Yu, C.P. ; Sun, G.H. ; Lin, Y.F. ; Chiang, H. ; Chao, T.K. ; Tsai, W.C. ; Sheu, L.F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Aim: To determine whether higher
expression of fascin, an actin-bundling protein
associated with motility, in conventional renal cell
carcinoma (RCC) is associated with more advanced
stages of the disease. Methods: Immunohistochemical
analysis of fascin expression was performed in tissue
microarrays of 108 RCCs including 55 clear cell RCCs
(CRCCs), 39 CRCCs with granular cell differentiation
(GRCCs), 8 CRCCs with sarcomatoid differentiation
(SRCCs) and 6 metastatic RCCs. Results: The
expression of fascin was undetectable in normal renal
tubules of all control cases. However, among the 108
RCC cases, fascin immunoreactivity was seen on the cell
membrane and cytoplasm. The average immunostaining
score for fascin was 128/400 in grade I, 170/400 in grade
II, 207/400 in grade III, and 323/400 in grade IV RCC.
The average immunostaining score of fascin was
187/400 for stage T1, 205/400 for stage T2, 288/400 for
stage T3, and 355/400 for stage T4 cases of RCCs.
Higher fascin scores in RCC were significantly
correlated with higher T and N stages and nuclear grade.
In addition, the fascin scores in GRCC (368±19) and
SRCC (263±21) were significantly higher than in CRCC 95±18). Conclusions: Our findings demonstrate for the
first time that increased expression of fascin is
associated with clinicopathological parameters of
aggressiveness in patients with RCC. Fascin may be a
novel biomarker for diagnosis and treatment of RCC.
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