Publication: Fish tales: The use of zebrafish xenograft human cancer cell models
Authors
Drabsch, Yvette ; Snaar Jagalska, Ewa ; Ten Dijke, Peter
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
DOI: 10.14670/HH-11-853
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Advances in scientific techniques have
provided researchers with exceptional new opportunities
to identify and monitor changes between different cancer
types, during different stages of progression, between
individual tumor cells and in the surrounding stroma.
The wealth of information that can be obtained from
new scientific techniques places additional requirements
on the conventional cancer models. New models that
could be used to rapidly access the (potential) functional
importance of newly identified (epi)genetic and
proteomic changes and test the efficacy on emerging
(combinatorial) therapies are desperately required. The
distinctive characteristics of zebrafish are progressively
being applied to create more relevant models of human
diseases. Zebrafish embryos provide a powerful tool to
develop functional cancer models. This is a tool that can
be used from drug discovery and development to
assessment of drug toxicity. This review will summarise
the use of zebrafish xenograft models to study human
cancers, and discuss the benefits and limitations of these
models.
publication.page.subject
Citation
Histology and Histopathology, Vol.32, nº7, (2017)
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/