Publication: Effect of hypertension and captopril treatment on the vasopressin in the rat median eminence and posterior lobe of the hypophysis. An immunohistochemical study
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Date
1999
Authors
Castañeyra Perdomo, A. ; Pérez Delgado, M.M. ; Carmona-Calero, E. ; Pérez-González, H. ; Marrero-Gordillo, N. ; Ferres Torres, R.
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Publisher
Murcia : F. Hernández
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Description
Abstract
The present study analyses the effects of
hypertension andlor its oral treatment with captopril
(angiotensine-converting enzyme inhibitor) on the rat
median eminence (ME) and the posterior lobe of the
hypophysis (PL). After an immunohistochemical
reaction using an antibody against arginine-vasopressin,
we compared by densitometry the amount of vasopressin
immunoreactive material (vasopressin-ir) of these
centers in 4 groups of animals: control Wistar Kyoto rats
(WKY), spontaneously hypertensive rats (SHR), WKY
rats treated with captopril (WKY-T) and SHR rats also
treated with the same drug (SHR-T). Captopril was
administrated at a dosage of 0.1 mglml in. the drinking
water from the 8th to the 15th weeks. We have found
that the rats showing the lowest level of vasopressin-ir,
in both ME and PL, were those from the SHR group, the
concentration increasing after oral captopril treatment
(SHR-T), although without reaching the values of WKY
rats. Then, ACE inhibition by captopril influences
vasopressin content in brain areas where the hormone is
concentrated before being released, which supports the
hypothesis that suggests a central modulatory effect of
ACE inhibitors, contributing to their therapeutic action
on hypertension.
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