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Cytostatic action of methylmercuric chloride on mammalian duodenal cells

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dc.contributor.authorCurle, D.C.es
dc.contributor.authorRay, M.es
dc.contributor.authorPersaud, T.V.N.
dc.contributor.authorBertalanffy, F.D.
dc.date.accessioned2011-01-17T12:40:13Z
dc.date.available2011-01-17T12:40:13Z
dc.date.issued1987
dc.description.abstractAdult male mice of the ICRISwiss Webster strain received a single intragastric administration of methylmercuric chloride 1,000 ppm, at dose levels of 5,10,15,20,25 and 30 mglkg of body weight. The animals were killed six hours later. Tissue samples from the duodenum were fixed in 10% neutral buffered formalin for light microscopy. Chromosome clumping was observed in dividing cells at all dose levels, resembling a C-mitotic effect. It would lead to reduced mitotic cell formation on account of the subsequent lysis of the arrested metaphases. The cytostatic effect was brought about by the inactivation of the microtubule spindle fiber polymerization mechanism induced by methylmercuric chloride. There was a direct positive correlation between the varying dose levels of methylmercury and the proportion of cells arrested in metaphase in the crypts of the duodenum.
dc.formatapplication/pdfes
dc.format.extent4es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/17887
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCytostatices
dc.subjectDuodenal cellses
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::575 - Genética general. Citogenética general. Inmunogenética. Evolución. Filogeniaes
dc.titleCytostatic action of methylmercuric chloride on mammalian duodenal cellses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 2, nº 3 (1987)