Publication: Ischemic preconditioning: tolerance to hepatic ischemia-reperfusion injury
Authors
Serafín, A. ; Fernández-Zabalegui, L. ; Prat, Narcis ; Wu, Z.Y. ; Roselló-Catafau, J. ; Peralta, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Hepatic ischemia-reperfusion (I/R) injury
still remains an unresolved problem in both liver
resectional surgery and liver transplantation and may be
responsible for liver failure, lung injury and death. The
current review summarizes the findings reported to date
on the effectiveness of ischemic preconditioning against
liver and lung damage associated with hepatic I/R injury
and the underlying protective mechanisms. The effect of
ischemic preconditioning on the mechanisms potentially
involved in hepatic I/R injury, including alterations in
energy metabolism, neutrophil accumulation,
microcirculatory disturbances, formation of
proinflammatory mediators, such as endothelin and
tumor necrosis factor-alpha, and reactive oxygen species
generation have been evaluated. In this review, we
address the role of preconditioning in the increased
vulnerability of fatty livers to hepatic I/R injury. The
effectiveness of ischemic preconditioning versus
pharmacological strategies that could simulate the
benefits of liver preconditioning has been also discussed.
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Citation
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