Publication: Ultrastructural alterations of the rabbit sciatic nerve, spinal cord and cerebellum, following
methionine sulphoximine administration
Authors
Kallaras, C. ; Anogianakis, G. ; Apostolakis, M. ; Manthos, A. ; Sioga, A. ; Economou, L. ; Foroglou, Ch.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Methii~nine suluhoximine (MSO) is a
centrally ácting neurutoxin wh'ich inhibits the glutainate
nietabolism enzymes and has convulsive properties.
Sniall doses of MSO were administered to rabbits. either
intra\,eiiously (IV) or intracerebroventricularly (ICV),
anil electron microscopic examination of the cerebellum.
the spinal cord and the sciatic nerve was perforined on
the first day of rabbit hind leg rigid paralysis (myopathy
with histvlogical findings resenibling myositis). which
set in by [he 2nd to 4th day after MSO administration. In
thc cerebelluin focal minor alterations were hund in the
astrocytes (swelling and lucidity. diminution of glycogen
graiiules) and sparsely in the presynaptic terminals
(luciditj. and clumping). whereas inost of the neuron
prescnted a nornial appearance. In the spinal cord and in
the sciatic nerve a dissociation of the axon from the
iiiyelin shcath was evident in a small number of
niyelinatcd nerve fibres, along with the appearance of
vacuolated spaces. Mitochondrial disorganisation in the
axons. as well as glial cell alterations, were also seen.
Th c u l t r a s t r u c t ~ ~ r aall terat ions we r e non spe c i f i c ,
Lind siiice they wcre induced 2 to 4 days after the
adniiriistration of either minimum doses (IV) or of
exti-cmely low doses (ICV) of MSO, they inay be
attributed to the inordinate increase of metabolism
during the period of convulsions.
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