Publication: Neuroectodermal grafting: A new tool for the study of neurodegenerative diseases
Loading...
Date
1996
Authors
Isenmann, S. ; Brandner, S. ; Aguzzi, A.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Transgenic and knockout mice have
contributed much to our current understanding of the
role played by single genes during development and in
pathological processes of the CNS, such as neurodegeneration.
However, embryonic lethality resulting
from the disruption of important genes has often
hindered the interpretation of such experiments. Grafting
of immature cells from genetically modified organisms
into healthy recipients promises to efficiently bypass this
problem. We have used neural transplantation techniques
which allow us to keep CNS tissue of knockout and
transgenic mice viable for a prolonged period of time in
the brain or in the kidney capsule of healthy recipients.
We have characterized biological parameters such as
growth, proliferation and differentiation and also the
formation of an intact blood-brain barrier (BBB) after
grafting of wild-type telencephalic anlage in this system.
We have also employed this technique to study the longterm
properties of neuroepithelial tissue derived from
knockout mice. The results of our studies are discussed
in the context of neurodegenerative diseases.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.