Publication: Sustanon induces dose-independent hypertrophy and satellite cell proliferation in slow oxidative fibers of avian skeletal muscle
Authors
Allouh, Mohammed Z. ; Jarrar, Ahmad A. ; Asfour, Hasan A. ; Said, Raed S. ; Shaqoura, Emad I.
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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Description
Abstract
Sustanon is a well-known anabolic drug that
is used to treat hypogonadism and restore muscle mass
and bone density. As research to date has been limited to
its effects in glycolytic fibers, this study aimed to
investigate the dose-related effects of Sustanon on the
oxidative fibers of avian skeletal muscle. Adult female
chickens were randomly divided into 4 groups: control
(C), received a dose of 100 μl normal saline per
injection; and Sustanon-1, -2, and -3 (S1, S2, and S3),
that received a dose of 12.5, 25, or 50 mg/kg Sustanon
per injection, respectively. Each bird received 4
injections at weekly intervals (1 injection/week). Robust
histochemical and immunofluorescent techniques along
with morphometric analyses were applied to determine
the oxidative activity and morphological variations of
the oxidative muscle fibers in all groups. Sustanontreated groups exhibited significant increases in fiber
size and numbers of satellite cells and myonuclei
compared to the control group. However, no significant
variations were found between Sustanon-treated groups
in the aforementioned indices. In conclusion, Sustanon
induced oxidative fiber hypertrophy that was associated
with satellite cell proliferation and myonuclear accretion
in avian skeletal muscle. Furthermore, the effects of
Sustanon appeared to be dose-independent.
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