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Role of discoidin domain receptor 2 in wound healing

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dc.contributor.authorMárquez, Joana
dc.contributor.authorOlaso, Elvira
dc.date.accessioned2019-11-25T15:00:30Z
dc.date.available2019-11-25T15:00:30Z
dc.date.issued2014
dc.description.abstractUntil recently, collagen interactions with cells had been ascribed to integrins. The identification of the Discoidin Domain Receptor (DDR) family as collagen receptors represents a new paradigm in the regulation of collagen-cell interactions. How DDR signaling is biochemically linked to specific cell regulatory functions remains largely unknown. Moreover, the characteristic slow and substained phosphorylation of DDRs and the elevated expression of DDR2 in the myofibroblasts of healing wounds suggest a role for DDR2 in physiological and pathological wound healing. In fact, DDR2 signaling regulates cell proliferation and extracellular matrix synthesis, which are key aspects of fibroblast contribution to tissue healing. In this review we summarize evidence in favor of this concept.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.doihttps://doi.org/10.14670/HH-29.1355
dc.identifier.eisbnHistology and Histopathology, Vol. 29, n.º 11 (2014)es
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/76908
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCollagenes
dc.subjectDiscoidin domain receptorses
dc.subjectMyofibroblastes
dc.subjectReceptores
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleRole of discoidin domain receptor 2 in wound healinges
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº11 (2014)