Publication: Peptidergic innervation in
Authors
Kusakabe, T. ; Tawakami, T. ; Takenaka, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The amphibian carotid labyrinth, which
corresponds to the mammalian carotid body and
carotid sinus, is innervated by nerve fibers containing
substance P (SP), calcitonin gene-related peptide
(CGRP), vasoactive intestinal polypeptide (VIP),
neuropeptide Y (NPY). FMRFamide (FMRF). and
somatostatin (SOM). SP, CGRP, VIP, and NPY
immunoreactive varicose fibers are more densely
distributed in the peripheral portion of the carotid
labyrinth than FMRF and SOM fibers. The time of
appearance of SP, CGRP. and VIP is different for
each. First CGRP fibers, then SP fibers appear at an
early stage of larva1 development, and finally VIP fibres
are detected at a later stage of larva1 development. Most
SP fibres show coexistence with CGRP, and some SP
fibres which show coexistence with NPY immunoreactivity
are assumed to be continuous with those
demonstrating VIP immunoreactivity. This indicates
the possibility of coexistence of four different peptides
in the same nerve fibers within the labyrinth. In
various vasculatures of mammals, it has been shown
that SP, CGRP, VIP, and NPY have a vasoactive nature
in relation to the vascular smooth muscle cells. On this
basis, it seems that the target of the peptidergic
innervation in the amphibian carotid labyrinth is the
smooth muscle cells which are abundantly distributed in
the intervascular stroma. Accordingly, the peptidergic
innervation may be involved in the vascular regulatory
function of the labyrinth, although the possibility that
these peptides participate in the chemoreception cannot
be ruled out. In addition, the vascular regulatory function
of the labyrinth may be modulated by the interaction of
multiple neuropeptides.
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