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Mitochondrial cholesterol in health and disease

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dc.contributor.authorGarcia-Ruiz, Carmenes
dc.contributor.authorMari, Monserrates
dc.contributor.authorColell, Ana
dc.contributor.authorMorales, Albert
dc.contributor.authorCaballero, Francisco
dc.contributor.authorMontero, Joan
dc.contributor.authorTerrones, Ohiana
dc.contributor.authorBasañez, Gorka
dc.contributor.authorFernández-Checa, José C.
dc.date.accessioned2013-09-24T11:05:57Z
dc.date.available2013-09-24T11:05:57Z
dc.date.issued2009
dc.description.abstractCholesterol is a critical component of biological membranes, which not only plays an essential role in determining membrane physical properties, but also in the regulation of multiple signaling pathways. Cells satisfy their need for cholesterol either by uptake from nutrients and lipoproteins or de novo synthesis from acetyl-CoA. The latter process occurs in the endoplasmic reticulum, where transcription factors that regulate the expression of enzymes involved in the de novo cholesterol synthesis reside. Cholesterol is distributed to different membranes most prominently to plasma membrane, where it participates in the physical organization of specific membrane domains. Mitochondria, however, are considered cholesterol-poor organelles, and obtain their cholesterol load by the action of specialized proteins involved in its delivery from extramitochondrial sources and trafficking within mitochondrial membranes. Although mitochondrial cholesterol fulfills vital physiological functions, such as the synthesis of bile acids in the liver or the formation of steroid hormones in specialized tissues, recent evidence indicates that the accumulation of cholesterol in mitochondria may be a key step in disease progression, including steatohepatitis, carcinogenesis or Alzheimer disease.es
dc.formatapplication/pdfes
dc.format.extent16es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/35966
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCholesteroles
dc.subjectMitochondriaes
dc.subject.other61 - Medicinaes
dc.titleMitochondrial cholesterol in health and diseasees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24, nº1 (2009)