Publication: Dendritic cell migration and lymphocyte homing imprinting
Authors
Villablanca, Eduardo J. ; Russo, Vicenzo ; Rodrigo Mora, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
For an effective adaptive immune response to
occur, dendritic cells (DC), which are the most efficient
antigen-presenting cells, must be able to sample the
peripheral microenvironment and migrate towards
secondary lymphoid organs (SLO) where they activate
naïve lymphocytes. Upon activation, lymphocytes
proliferate and acquire the capacity to migrate to
extralymphoid compartments. Although the molecular
mechanisms controlling lymphocyte homing to
lymphoid and to some extralymphoid tissues have been
described in significant detail, it is much less clear how
DC migration is controlled. Do DC obey similar
adhesion cues that lymphocytes do, or do they have their
own “zip codes”? This is relevant from a therapeutic
standpoint because effective DC-based vaccines should
be able to reach the appropriate tissues in order to
generate protective immune responses. Here, we discuss
some of the mechanisms used by DC to reach their target
tissues. Once DC arrive at their destination, they are
exposed to the tissue microenvironment, which likely
modulates their functional properties in a tissue-specific
fashion. This local DC “education” is probably
responsible among other things; for the acquisition of
tissue-specific homing imprinting capacity by which DC
instruct lymphocytes to migrate to specific tissues. Finally, we discuss how dysregulation of these signals
may play a key role in disease.
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