Publication: Expression of OAT1 and OAT3 in differentiating proximal tubules of the mouse kidney
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Date
2010
Authors
Hwang, Jin-Sun ; Park, Eun-Young ; Kim, W.J. ; Yang, Chul-Woo ; Kim, Jin
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Organic anion transporter 1 (OAT1) and
OAT3 in the proximal tubules (PT) of the kidney play
important roles in the elimination of harmful
endogenous compounds and xenobiotics from the body.
We investigated the temporal and spatial expression of
OAT1 and OAT3 in the differentiating PT in mouse
kidney. Ontogenic expression of OAT1 and OAT3 was
investigated by immunohistochemical analysis. The S1,
S2, and S3 segments of the PT were identified using
antibodies to aquaporin 1 (AQP1), Na+-HCO3
–
cotransporter 1 (kNBC1), and AQP4. OAT1
immunoreactivity was first detected at PT in the inner
cortex of 15-day-old fetuses (F15) and in the outer
cortex of 7-day old pups. OAT3 was first observed in the
distal tubule of F14 and in S2 segment of the PT of F16
and in S1 and S3 segments around the time of birth;
expression increased through postpartum day 21. The
ontogenic pattern of expression of OAT1 and OAT3 in
the differentiating PT suggests that both transporters
may function in the S2 segment in the fetus, but not until
after birth in S1 and S3 segments.
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