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Telocytes form networks in normal cardiac tissues

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dc.contributor.authorRusu, Mugurel Constantin
dc.contributor.authorPop, F.
dc.contributor.authorHostiuc, S.
dc.contributor.authorCurca, G.C.
dc.contributor.authorJianu, A.M.
dc.contributor.authorPaduraru, D.
dc.date.accessioned2017-03-13T17:24:09Z
dc.date.available2017-03-13T17:24:09Z
dc.date.issued2012
dc.description.abstractTelocytes (TC) are a class of interstitial cells present in heart. Their characteristic feature is the presence of extremely long and thin prolongations (called telopodes). Therefore, we were interested to see whether or not TCs form networks in normal cardiac tissues, as previously suggested. Autopsy samples of cardiac tissues were obtained from 13 young human cadavers, without identifiable cardiac pathology and with a negative personal history of cardiovascular disease. Immunohistochemistry on formalin-fixed paraffin-embedded tissues was performed using monoclonal antibodies for CD117/c-kit. Additionally, ventricular samples from 5 Sprague-Dawley rats were ultrastructurally evaluated under transmission electron microscopy. We found c-kit positive cells with TC features in subepicardium, as well in subepicardial arteries and in subepicardial fat. TCs were also present in the subendocardium. Light and electron microscopy revealed the existence of intramyocardial networks built up by bipolar TCs. Larger c-kit positive multipolar TCs were found between cardiac muscle bundles. Our results support the existence of a cardiac network of telocytes.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.eisbnHistology and Histopatholy, Volume 27, number 6 (June), 2012es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/52463
dc.languageenges
dc.publisherF. Hernandez y JuanF. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología.es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectTelocyteses
dc.subjectMyocardiumes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biologíaes
dc.titleTelocytes form networks in normal cardiac tissueses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº 6 (2012)