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Immunocytochemical localization of myotonin protein kinase on muscle from patients with congenital myotonic dystrophy

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Immunocytochemical localization of myotonin protein kinase on muscle from patients with congenital myotonic dystrophy.pdf(1.48 MB)
Date
1996
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Authors
Tachi, N. ; Kozuka, N. ; Ohya, K. ; Chiba, S. ; Kikuchi, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Using a polyclonal anti myotonin-protein kinase (M-PK) antibody against synthetic M-PK peptides corresponding to part of the amino acid sequence, and the immunohistochemical analysis of indirect immunoperoxidase, we have investigated localization of M-PK on muscle from patients with congenital myotonic dystrophy. In congenital myotonic dystrophy (MD) patients, one month and 3 months old, M-PK was weakly expressed at sarcolemma of muscle fibers. In congenital MD patients from 2 to 9 years of age, M-PK was clearly expressed at sarcolemma of muscle fibers. M-PK of immature muscle is weakly expressed at sarcolemma. With aging, M-PK is clearly expressed at sarcolemma of muscle from MD patient and normal control.
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Myotomin dystrophy , Myotonin protein kinase
Citation
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http://hdl.handle.net/10201/18877
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Histology and histopathology Vol.11, nº 4 (1996)
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