Publication: Changes in intestinal endocrine cells in the mouse after unilateral cervical vagotomy
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Date
1999
Authors
Qian, B.F. ; El-Salhy, M. ; Danielsson, A. ; Shalaby, A. ; Axelsson, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effect of right or left unilateral cervical
vagotomy on the intestinal endocrine cells was studied in
23 mice at 2 and 8 weeks after operation, respectively.
The results were compared with that from 10 sham
operated mice. Various types of endocrine cells in
duodenum and proximal colon were detected by
immunohistochemistry and quantified by computerized
image analysis. In mouse duodenum, chromogranin-,
CCKIgastrin-, GIP- and somatostatin-cells were
significantly decreased at 2 weeks after right vagotomy,
but returned to the control levels at 8 weeks. Serotonincells
were reduced at both 2 and 8 weeks after right
vagotomy. The amount of the duodenal endocrine cells
did not change after left vagotomy with the exception of
secretin-cells, which were diminished at 8 weeks after
both right and left vagotomy. In the proximal colon,
chromogranin-cells were also decreased at 2 weeks after
right vagotomy. Serotonin-cells were reduced at 8 weeks
after left vagotomy but not right vagotomy. There was
no significant difference between the unilaterally vagotomized
and the sham operated mice with regard to
PYY- and glucagon-cells. It was concluded that
vagotomy affected the intestinal endocrine cells in
mouse. The influence was more pronounced in the small
intestine than the proximal colon. The right vagus nerves
seemed to exert more effect on the intestinal endocrine
cells than the left ones.
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