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C-reactive protein levels are associated with the progression of atherosclerotic lesions in rabbits

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dc.contributor.authorYu, Qi
dc.contributor.authorLi, Yafeng
dc.contributor.authorWang, Yanli
dc.contributor.authorZhao, Sihai
dc.contributor.authorYang, Peigang
dc.contributor.authorChen, Yulong
dc.contributor.authorFan, Jianglin
dc.contributor.authorLiu, Enqi
dc.date.accessioned2017-03-10T19:21:37Z
dc.date.available2017-03-10T19:21:37Z
dc.date.issued2012
dc.description.abstractElevated plasma levels of C-reactive protein (CRP) are associated with increased risk of cardiovascular disease. CRP immunoreactive protein is also detected in the lesions of atherosclerosis. However, it is not known whether the CRP contents of atherosclerotic lesions are associated with the initiation and progression of atherosclerosis. To examine this hypothesis, we investigated different types of atherosclerotic lesions of rabbits fed with a cholesterol-rich diet for 6, 12, 16, and 28 weeks and examined their relationship with CRP. We measured the aortic atherosclerotic area, macrophages, and smooth muscle cells along with CRP contents in the lesions. Atherosclerotic lesions of aortas began to form at 6 weeks and were characterized by accumulation of macrophages in the intima, and lesions became more fibrotic in the advanced stage. Both plasma CRP levels and the lesional CRP contents were associated with the lesion size. Our results suggest that plasma CRP, as well as lesional CRP, associated with the formation and progression of atherosclerotic lesions.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.eisbnHistology and histopathology, Vol. 27, nº 4 (2012)es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/52429
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectInflammationes
dc.subjectAtherosclerosises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleC-reactive protein levels are associated with the progression of atherosclerotic lesions in rabbitses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº 4 (2012)