Publication: The role of neurotrophins related to stress in saliva and salivary glands
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Date
2010
Authors
Saruta, Juri ; Sato, Sadao ; Tsukinoki, Keiichi
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Nerve growth factor (NGF) and brainderived
neurotrophic factor (BDNF) are well-studied
neurotrophins involved in neurogenesis, differentiation,
growth, and maintenance of selected peripheral and
central populations of neuronal cells during development
and adulthood. Neurotrophins, in concert with the
hypothalamic-pituitary-adrenal (HPA) axis, play key
roles in modulating brain plasticity and behavioral
coping, especially during ontogenetic critical periods,
when the developing brain is particularly sensitive to
external stimuli. Early life events, such as
psychophysical stress, affect NGF and BDNF levels and
induce dysregulation of the HPA axis, thereby affecting
brain development and contributing to inter-individual
differences in vulnerability to stress or psychiatric
disorders. Immobilization stress modifies BDNF mRNA
expression in some organs. We studied the effect of
immobilization stress on BDNF and its receptor tyrosine
receptor kinase B (TrkB) in rat submandibular glands,
and found increased BDNF expression in duct cells
under immobilization stress. Upon further investigation
on the influence of salivary glands on plasma BDNF
using an acute immobilization stress model, we found
that acute immobilization stress lasting 60 min
significantly increases the plasma BDNF level.
However, plasma BDNF elevation is markedly
suppressed in bilaterally sialoadenectomized rats. This
suggests that salivary glands may be the primary source
of plasma BDNF under acute immobilization stress. This
report reviews the structure of salivary glands, the role
of neurotrophins in salivary glands, and the significance of BDNF in saliva and salivary glands, followed by a
summary of the evidence that indicates the relationship
between immobilization stress and BDNF expression
within salivary glands.
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