Publication: Ontogenic attendance of
neuropeptides in the embryo chicken retina
Authors
Prada Oliveira, J. A. ; Verastegui, C. ; Gómez Luy, C. ; Collantes Ruiz, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We have examined the ontogeny of
somatostatin-, Glucagon-, Vasoactive Intestinal
Polypeptide-, Substance P-, Neuropeptide Y, and
Calcitonin gene-related peptide-Iike structures in the
chicken retina by immunocytochemistry. Neuroblastic
cells containing Substance P-Iike immunoreactivity (IR)
first appeared at embryonic day 5 in the peripheral
portion of the retina. Somatostatin-like immunoreactivity
was detected as early as embryonic day 11 in the
innermost level of the inner neuroblastic layer. The
distribution pattern of amacrine cells containing
Vasoactive Intestinal Peptide-Iike immunoreactivity was
similar to that for Neuropeptide Y- and Calcitonin generelated
peptide-Iike immunoreactive cells. These three
types of IR cell appeared at embryonic day 13.
Glucagon-like immunoreactive cells first appeared in the
retina at embryonic day 15, in the innermost part of the
inner nuclear layer. From the 13th to 15th day of
incubation, the number and intensity of Calcitonin generelated
peptide-, Somatostatin-, Neuropeptide Y- and
Substance P-Iike immunoreactive cells increased and
then decreased progressively before hatching. Glucagon
immunoreactive cells increased in number on the last
day before hatching. After embryonic day 15, the
amacrine cells containing Vasoactive intestinal peptide-
Iike immunoreactivity decreased notably in number. Our
study showed that development of these immunoreactive
structures was different for each neuropeptide. These
differences in development may reflect the diverse
neurophysiological roles of these neuroactive peptides,
which could act as neurotransmitters/neuromodulators at
the chick retinal level. Their presence may indicate roles
as neuronal differentiation or growth factors.
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