Publication: Neuromedins and their involvement in the regulation of growth, structure and function of the adrenal cortex
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Date
1994
Authors
Malendowicz, L.K. ; Markowska, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Current data on the synthesis and the
mechanism of action of neuromedins on adrenal cortex
are presented. The localization of these biologicallyactive
peptides in all components of the hypothalamopituitary-
adrenal axis as well as their action on the
adrenal cortex both in vivo and in vitro suggest their
involvement in the regulation of growth, structure and
function of the adrenal cortex. Neuromedins may exert
both direct and indirect effect on the adrenal cortex.
Direct effect is proven by the stimulation of glucocorticoid
synthesis by adrenocortical cells in culture
(NMK, NML) while indirect effects may be mediated by
ACTH, vasopressin (aldosterone secretagogue effect)
and angiotensin (prompt proliferative response) or by
substances of medullary origin. The last mechanism of
action is well documented for NMU.
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