Publication: Gap junctions and expression of Cx36 Cx43 and Cx45 in the posterodorsal medial amygdala of adult rats
Authors
Zancan, Mariana ; Malysz, Tais ; Moura, Dinara J. ; Morás, Ana Moira ; Steffens, Luiza ; Rasia-Filho, Alberto
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-160
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info:eu-repo/semantics/article
Description
Abstract
The posterodorsal medial amygdala (MePD)
has a synaptic organization that dynamically modulates
reproduction and other social behaviors in rats. Discrete
gap junctions between glial cells were previously
reported in the MePD neuropil. Connexins (Cx) are
components of gap junctions and indicative of cellular
electrical coupling. Here, we report the ultrastructural
occurrence of gap junctions between neurons in the
MePD and demonstrate the expression and
immunofluorescent labeling of Cx36, Cx43 and Cx45 in
this subcortical area of adult male rats. Few neuronal gap
junctions were found in the MePD and, when identified,
occurred between dendrites. On the other hand, there is a
diffuse presence and distribution of punctate labelling
for the tested Cxs. Puncta were visualized isolated or
forming clusters in the same focal plane of cell bodies or
along the MePD neuropil. The Cx36 puncta were found
in neurons, Cx43 in astrocytes and Cx45 in both neurons
and astrocytes. Our data indicate the presence of few gap
junctions and different Cxs composition in the MePD.
Because Cxs can assemble, form hemichannel units
and/or serve as transcriptional regulator, it is likely that
additional modulation of intercellular communication
can occur besides the chemical transmission in the
MePD of adult rats.
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