Publication: Interaction between cell and
extracellular matrix in heart disease:
Multiple roles of tenascin-C in tissue remodeling
Authors
Imanaka-Yoshida, K. ; Hiroe, M. ; Yoshida, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The heart remodels myocardial tissue in
physiological and pathological response. The cellextracellular
matrix (ECM) interaction provides not only
structural and mechanical support but also important
biological signaling during tissue remodeling. Among
various ECM molecules, tenascin-C (TNC) is well
known as a regulator of multiple cellular functions
during embryogenesis, wound healing or cancer
progression. In the heart, TNC appears in several
important steps of embryonic development such as the
initial differentiation of cardiomyocytes or coronary
vasculo/angiogenesis, but it is not detected in a normal
adult myocardium. However, TNC is found to re-express
after myocardial injury and may regulate cellular
behavior during tissue remodeling by modulating the
attachment of cardiomyocytes to connective tissue, by
enhancing migration and differentiation of
myofibroblasts, and by inducing matrix metalloproteinases.
TNC also interacts with other ECM
molecules and may modulate progression of fibrosis.
Furthermore, transient and site specific expression of
TNC closely associated with myocardial injury and
inflammation suggests not only its key roles during
tissue remodeling but also that TNC can be a marker for
myocardial disease activity.
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