Publication: Altered growth pattern, not altered growth per se, is the hallmark of early lesions preceding cancer development
Authors
Doratiotto, Silvia ; Marongiu, Fabio ; Faedda, Simona ; Pani, Paolo ; Laconi, Ezio
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Many human solid cancers arise from focal
proliferative lesions that long precede the overt clinical
appearance of the disease. The available evidence
supports the notion that cancer precursor lesions are
clonal in origin, and this notion forms the basis for most
of the current theories on the pathogenesis of neoplastic
disease. In contrast, far less attention has been devoted
to the analysis of the phenotypic property that serves to
define these focal lesions, i.e. their altered growth
pattern. In fact, the latter is often considered a mere
morphological by-product of clonal growth, with no
specific relevance in the process. In the following study,
evidence will be presented to support the concept that
focal growth pattern is an inherent property of altered
cells, independent of clonal growth; furthermore, it will
be discussed how such a property, far from being merely
descriptive, might indeed play a fundamental role in the
sequence of events leading to the development of cancer.
Within this paradigm, the earliest steps of neoplasia
should be considered and analysed as defects in the
mechanisms of tissue pattern formation.
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