Publication: Characteristics of lymphatic endothelial cells
in physiological and pathological conditions
Authors
Ji, R.C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Impairment of lymphatic structure and
function, e.g., inadequate endothelial permeability and
intercellular openings, abnormal lymphangiogenesis and
overexpression for immunoreactive agents, will result in
tumor metastasis, autoimmune response alteration and
accumulation of interstitial fluid and proteins. Recently,
several novel molecules have been identified that allow a
more precise distinction between lymphatic and blood
vascular endothelium. The differences in expression of
endothelial markers on the lymphatic vessel strongly
suggest the possibility that there will be important
divergence in the differentiating and regenerating
responses in lymphatic behavior to various pathological
processes. Undoubtfully, molecular techniques would
also lead to the definition of unique markers found on
lymphatic endothelial cells (LECs) in lymphaticassociated
diseases which are mostly involved in
lymphangiogenesis. This review is mainly concentrated
on the characteristics of LECs in diabetes, wound
healing, lymphedema and tumor, especially in the
experimental models that have offered insight into the
LEC role in these diseases affecting the lymphatic
system. Increased knowledge of the molecular signaling
pathways driving lymphatic development and
lymphangiogenesis should boost the impact of
therapeutics on the diseases. Although the field about the
mechanisms that control the formation and lineagespecific
differentiation and function of lymphatic vessels
has experienced rapid progress in the past few years, an
understanding of the basis of the differences and their
implications in the pathological conditions will require
much more investigation.
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