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Primary extranodal vaginal non-hodgkin lymphoma: Diagnostic pitfalls and therapeutic challenges

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dc.contributor.authorPetrillo, Marco
dc.contributor.authorFara, Antonella Maria
dc.contributor.authorFedeli, Maria Antonietta
dc.contributor.authorFozza, Claudio
dc.contributor.authorCossu, Antonio
dc.contributor.authorGulotta, Alessandra
dc.contributor.authorDessole, Francesco
dc.contributor.authorPiana, Andrea
dc.contributor.authorCapobianco, Giampiero
dc.contributor.authorTanda, Francesco
dc.contributor.authorDessole, Salvatore
dc.date.accessioned2022-07-04T09:25:44Z
dc.date.available2022-07-04T09:25:44Z
dc.date.issued2019
dc.description.abstractIntroduction. Primary extranodal nonhodgkin vaginal lymphoma (PeNHVL) represents a rare entity, with few data published until now. We present here a series of patients with PeNHVL, analyzing our data as part of a detailed review of the available literature. Methods. The study included a consecutive series of 6 patients with final diagnosis of PeNHVL admitted at our Institution between January 2000 and December 2017. The systematic review was conducted according to PRISMA guidelines. A literature search of the PubMed, MEDLINE and EMBASE electronic databases was performed using the following terms: ‘vaginal lymphoma’. Relevant data were collected and analyzed for the purposes of this study, reporting results through a narrative approach. Results. In our series discomfort and vaginal pain, refractory to medical treatments represent the symptoms of disease presentation, and the presence of localized/diffused anelastic area in the vaginal wall with tactile sensation of cork emerges as diagnostic sign (Cork Wall sign). The literature revision included 41 studies, with an overall population of 74 patients. The vast majority of women were diagnosed as early stage disease (93.6%) and received chemotherapy (74.6%) with a very high response rate (96%). Death from disease occurred in 5 women (6.7%). Conclusions. Localized or diffused hard-ligneous vaginal areas with Cork Wall sign represent the typical sign of disease presentation. PeNHVL is characterized by a very high sensitivity to chemotherapy and very favourable prognosis; therefore, radical surgery is not indicated. Histotype characterization is crucial to identify those uncommon variants associated with a less favorable clinical outcome.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.doiDOI: 10.14670/HH-18-085
dc.identifier.eisbnHistology and Histopathology, Vol.34, nº7, (2019)es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/122068
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCork wall signes
dc.subjectPrimary extranodales
dc.subjectNonhodgkin lymphomaes
dc.subjectVaginaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titlePrimary extranodal vaginal non-hodgkin lymphoma: Diagnostic pitfalls and therapeutic challengeses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34, nº7 (2019)