Publication: Downregulation of nuclear ING3 expression and translocalization to cytoplasm promotes tumorigenesis and progression in head and neck squamous cell carcinoma (HNSCC)
Authors
Li, Xiaohan ; Zhang, Qun ; Zhang, Mingming ; Luo, Yusong
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-197
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info:eu-repo/semantics/article
Description
Abstract
ING3 (inhibitor of growth gene 3) is a
member of the ING gene family, and is considered as a
candidate tumor suppressor gene. In order to explore the
roles of ING3 in tumorigenesis and cancer progression
of head and neck squamous cell carcinoma (HNSCC),
ING3 expression was assessed in 173 cases of HNSCC
by immunohistochemistry. The expression of ING3 was
also compared to clinicopathological variables, and the
expression of several tumorigenic markers. Nuclear
expression of ING3 in HNSCC was significantly lower
than that in dysplasia and normal epithelium, and was
negatively correlated with a poor-differentiated status, T
staging and TNM staging. In contrast, cytoplasmic
expression of ING3 was significantly increased in
HNSCC, and was statistically associated with lymph
node metastasis and 14-3-3η expression. In addition,
nuclear expression of ING3 was positively correlated
with the expression of p300, p21 and acetylated p53. In
conclusion, decreases in nuclear ING3 may play
important roles in tumorigenesis, progression and tumor
differentiation in HNSCC. Increases in cytoplasmic
ING3 may be due to 14-3-3η binding and may also be
involved in malignant progression. Nuclear ING3 may
modulate the transactivation of target genes, promoting
apoptosis through interactions with p300 and p21.
Moreover, ING3 may interact with p300 to upregulate
the level of acetylation of p53, and promote p53-
mediated cell cycle arrest, senescence and/or apoptosis.
Therefore, ING3 may be a potential tumor suppressor
and a possible therapeutic target in HNSCC
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