Publication: Principies of MHC class 1-mediated antigen presentation and T cell selection
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Date
1996
Authors
Ljunggren, H.G. ; Thorpe, C.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Class 1 molecules of the major histocompatibility
complex (MHC) are expressed on the cell
surface of almost al1 nucleated mammalian cells. Their
main function is to transport and present peptides,
derived from intracellularly degraded proteins, to
cytotoxic T cells (CTL). They are also directly involved
in the process leading to maturation and selection of a
functional CD8+ T cell repertoire. MHC class 1
molecules consist of a highly polymorphic membranespanning
heavy chain of approximately 45 kD that is
non-covalently associated with a light chain, B2-
microglobulin (B2m). Class 1 molecules bind peptides,
usually 8-11 amino acids in length. The majority of the
class 1-bound peptides are generated in the cytosol and
are subsequently translocated into the lumen of the
endoplasmic reticulum (ER) through the ATP-dependent
transporter associated with antigen processing 112
(TAP112). Here, we provide an up-to-date review
summarizing the most essential parts relating to MHC
class 1-mediated antigen processing, presentation and T
cell selection. A particular emphasis is devoted to the
structure of MHC class 1 molecule, and MHC class Ibound
peptides.
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