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Exercise-induced apoptosis in rat kidney is mediated by both angiotensin II AT1 and AT2 receptors

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dc.contributor.authorPodhorska-Okolow, M.es
dc.contributor.authorDziegiel, Piotres
dc.contributor.authorGomulkiewicz, A.
dc.contributor.authorKisiela, D.
dc.contributor.authorDolinska-Krajewska, B.
dc.contributor.authorJethon, Z.
dc.contributor.authorCarraro, U.
dc.contributor.authorZabel, M.
dc.date.accessioned2011-06-30T12:02:48Z
dc.date.available2011-06-30T12:02:48Z
dc.date.issued2006
dc.description.abstractExcessive physical exercise may lead to disturbance of the entire homeostasis in the body, including damage not only in skeletal muscles but also in many distant organs. The mechanisms responsible for the exercise-induced changes could include oxidative stress or angiotensin II. We previously showed that acute exercise led to apoptosis in kidney but not as a result of oxidative stress. In this study, we examined the role of angiotensin II and its AT1 and AT2 receptors in mediation of exercise-induced apoptosis in kidney. We clearly demonstrated that acute physical exercise induced apoptosis in renal cells of distal convoluted tubuli and cortical and medullary collecting ducts. Moreover, the cells displayed an increased expression of both AT1 and AT2 angiotensin II receptors and of p53 protein. The results suggest that angiotensin II could upregulate p53 expression in renal distal convoluted tubular cells and in the cells collecting ducts via both AT1 and AT2 receptors, which might be the crucial apoptosis-mediating mechanism in kidneys after excessive exercise.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22657
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectApoptosises
dc.subjectKidneyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleExercise-induced apoptosis in rat kidney is mediated by both angiotensin II AT1 and AT2 receptorses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.21, nº 5 (2006)