Publication: The therapeutic potential of human olfactory-derived stem cells
Authors
Marshall, C.T. ; Lu, C. ; Winstead, W. ; Zhang, X. ; Xiao, M. ; Harding, G. ; Klueber, K.M. ; Roisen, F.J.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Stem cells from fetal and adult central
nervous system have been isolated and characterized,
providing populations for potential replacement therapy
for traumatic injury repair and neurodegenerative
diseases. The regenerative capacity of the olfactory
system has attracted scientific interest. Studies focusing
on animal and human olfactory bulb ensheathing cells
(OECs) have heightened the expectations that OECs can
enhance axonal regeneration and repair demyelinating
diseases. Harvest of OECs from the olfactory bulb
requires highly invasive surgery, which is a major
obstacle. In contrast, olfactory epithelium (OE) has a
unique regenerative capacity and is readily accessible
from its location in the nasal cavity, allowing for harvest
without lasting damage to the donor. Adult OE contains
progenitors responsible for the normal life-long
continuous replacement of neurons and supporting cells.
Culture techniques have been established for human OE
that generate populations of mitotically active neural
progenitors that form neurospheres (Roisen et al., 2001;
Winstead et al., 2005). The potential application of this
technology includes autologous transplantation where
minimal donor material can be isolated, expanded ex vivo, and lineage restricted to a desired phenotype prior
to/or after re-implantation. Furthermore, these strategies
circumvent the ethical issues that arise with embryonic
or fetal tissues. The long term goal is to develop
procedures through which a victim of a spinal cord
injury or neurodegenerative condition would serve as a
source of progenitors for his/her own regenerative grafts,
avoiding the need for immunosuppression and ethical
controversy. In addition, these cells can provide
populations for pharmacological and/or diagnostic
evaluation.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.