Publication: Matrix-metalloproteinases in bronchopulmonary carcinomas
Authors
Martinella Catusse, C. ; Nawrocki, B. ; Gilles, C. ; Birembaut, P. ; Polette, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Matrix metalloproteinases (MMPs) represent
a group of enzymes involved in the degradation of most
of the components of the extracellular matrix and
therefore participate in tumoural invasion. MMPs,
especially gelatinases A and B, MT1-MMP, the activator
of gelatinase A, and stromelysin-3 were found overexpressed
in many cancers including bronchopulmonary
carcinomas. In vivo observations revealed that
fibroblasts are the principal source of production of
MMPs. Some of these enzymes such as MT1-MMP and
stromelysin 3, displayed a focal stromal localisation near
preinvasive and invasive tumour clusters. Futhermore,
some tumour cell lines were shown to stimulate the
expression of MT1-MMP by fibroblasts. All these in
vivo and in vitro results suggest that certain tumour cells
produce diffusible factors which could influence the
MMP stromal expression. Among these factors, the
TCSF (Tumor Collagenase Stimulatory Factor) which is
known to upregulate some MMPs in vitro could be a
good candidate for this stromal regulation, since it is
produced by bronchial tumour cells in vivo. In this
review, we address such a cooperation between tumour
and stromal cells for the production of MMPs and
emphasize their necessity for tumoural progression in
bronchopulmonary carcinomas.
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