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Review of acquired cystic disease-associated renal cell carcinoma with focus on pathobiological aspects

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dc.contributor.authorKuroda, Naoto
dc.contributor.authorOhe, Chisato
dc.contributor.authorMikami, Shuji
dc.contributor.authorHes, Ondrej
dc.contributor.authorMichal, Michal
dc.contributor.authorBrunelli, Matteo
dc.contributor.authorMartignoni, Guido
dc.contributor.authorSato, Yasuharu
dc.contributor.authorYoshino, Tadashi
dc.contributor.authorKakehi, Yoshiyuki
dc.contributor.authorShuin, Taro
dc.contributor.authorLee, Gang-Hong
dc.date.accessioned2016-04-28T15:05:34Z
dc.date.available2016-04-28T15:05:34Z
dc.date.issued2011
dc.description.abstractAcquired cystic disease (ACD)-associated renal cell carcinoma (RCC) is a recently established entity. In this article, we introduce the general view of this new entity. Macroscopically, the disease exclusively occurs in ACD and may arise as a dominant mass or non-dominant masses. Histologically, the tumor is characterized by a microcystic pattern, neoplastic cells with an eosinophilic or oncocytic cytoplasm and frequent intratumoral oxalate crystal deposition. Prominent nucleoli of tumor cells are often observed. Immunohistochemically, neoplastic cells are generally positive for AMACR but negative for cytokeratin 7. Ultrastructurally, neoplastic cells contain abundant mitochondria in the cytoplasm. Genetically, the gain of chromosomes 3, 7, 17 and abnormality of the sex chromosome were frequently observed in several studies. In conclusion, ACD-associated RCC may be widely recognized as a distinct entity in the near future because this tumor is morphologically and genetically different from other renal tumor entities that have been previously established.es
dc.formatapplication/pdfes
dc.format.extent4es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/49413
dc.languageenges
dc.publisherF. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología.es
dc.relation.ispartofHistology and histopathology, Vol. 26, nº9 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAcquired cystic diseasees
dc.subjectOxalate crystalses
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleReview of acquired cystic disease-associated renal cell carcinoma with focus on pathobiological aspectses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº9 (2011)