Publication: Cytotoxicity of Kuwait weathered lake crude oil on rat hepatocytes, a histological and ultrastructural study
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Date
1998
Authors
Safer, A.M. ; Meakins, R. ; Akbar, L. ; Abou-Salem, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In the present study, the cytotoxic effects of
Kuwaiti weathered crude oil and a potent carcinogen
(DMBA) on rat liver cells were examined by light and
electron microscopy at each of 4 sampling periods after
the start of low dosing (0.5 and 0.2 mg/kg) of feed. Such
effects were compared with those of olive oil and
uncontaminated food-exposed controls. The results
confirm a pronounced cell damage which statistically
not significant (p<0.05). In crude oil, the organelle
changes were variable and highly comparable to that of
DMBA. The nuclei were mostly disintegrated while the
cell showed demarcation of cytoplasmic vacuolization,
lipid augmentation, and mitochondrial aberrations. The
latter showed a remarkable association with the rough
endoplasmic reticulum and lipid droplets, and appeared
as decayed and diffused structures within the cell matrix.
There was no comparable changes in the hepatocytes of
animals fed with uncontaminated food except for the
formation of lipid droplets in the olive oil-fed groups.
Although the animals food was contaminated with
Kuwaiti weathered oil formed in 1991 were exposed to
extreme seasonal temperatures, yet the residues of such
oil led to severe histopathological alterations in the liver
cells which were similar to those of DMBA-treated cells.
There is the need to pay attention to potential hazardous
effects of the crude oil on environments.
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