Publication: Molecular biology of glioma tumorigenesis
Authors
Ware, M.L. ; Berger, M.S. ; Binder, D.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Gliomas are the most common intracranial
malignant tumors in humans, and high-grade gliomas in
particular pose a unique challenge due to their
propensity for proliferation and tissue invasion. Our
understanding of glioma oncogenesis, proliferation, and
invasion has been greatly advanced in the past 10 years
as researchers have gained a better understanding of the
molecular biology of these tumors. This article
highlights glioma histopathology, as well as cytogenetic
and molecular alterations associated with the
pathogenesis of human gliomas. It is hoped that better
understanding of the molecular pathogenesis of gliomas
will improve tumor classification as well as lead to novel
targets for therapy and prognostic markers.
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Citation
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