Publication: CSN6: a promising target for cancer prevention and therapy
Authors
Hou, Jianbing ; Cui, Hongjuan
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-206
item.page.type
info:eu-repo/semantics/article
Description
Abstract
CSN6 has recently received increased
attention as a multifunctional protein involved in protein
stability. CSN6 plays an important role in controlling
cellular proliferation, apoptosis and metastasis,
modulating signal transduction, as well as regulating
DNA damage and repair. Most studies have
demonstrated that CSN6 is significantly upregulated in
human malignant tumors such as cervical cancer,
papillary thyroid cancer, colorectal cancer, breast cancer,
lung adenocarcinoma, and glioblastoma, and its
expression is usually correlated with poor prognosis. In
this review, we summarize recent available findings
regarding the oncogenic role of CSN6 in tumors, and
provide a better understanding of CSN6 function at the
molecular level and its potential therapeutic implications
in combating human cancers
publication.page.subject
Citation
item.page.embargo
Ir a EstadÃsticas
Este Ãtem está sujeto a una licencia Creative Commons. CC BY 4.0