Publication: Ultrastructural changes in the synthetic and secretory patterns of pulmonary surfactant following pilocarpine in vivo
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Date
1997
Authors
Smith, Dennis M. ; Sommers Smith, Sally K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Previous studies have demonstrated that the
muscarinic agonist pilocarpine stimulates the secretion
of pulmonary surfactant from mammalian alveolar type
11 cells. The results of the present study quantify, via
ultrastructural stereologic analysis, this response through
24 hours. The cytoplasmic volume density of lamellar
bodies decreases significantly at 0.5 and 4 hours postinjection.
This value is increased significantly at 12
hours post-injection. Elements of the secretory apparatus
increase significantly at many of the post-injection
times. At 12 hours post-injection many of the type 11
cells are quite laden with lamellar bodies, with some
appearing surprisingly large. This may be a useful model
for continued study of the relationship between synthesis
and secretion of pulmonary surfactant.
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