Publication: Prognostic impact of perineural, blood and
lymph vessel invasion for esophageal cancer
Authors
Tachezy, Michael ; Tiebe, Anne-Kathrin ; Gebauer, Florian ; Kutup, Asad ; Tharun, Lars ; Pantel, Klaus ; Izbicki, Jacob Robert ; Vashist, Yogesh Kumar
item.page.secondaryauthor
item.page.director
Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-29.1467
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Background: With a median survival of <22
months esophageal cancer is one of the most aggressive
tumors, up to 20% of node negative patients develop
systemic relapse. Studies investigating the prognostic
impact of tumor-micro-invasion in blood (AI) and
lymphatic vessels (LVI) as well as perineural invasion
(PNI) have shown inconsistent results. The aim of the
present study was to investigate the prognostic value of
the aforementioned factors in a large homogenously
treated cohort of patients with esophageal cancer.
Methods: Data from 695 patients with surgically
treated esophageal cancer were analyzed. AI, LVI and
PNI were determined and data were statistically
correlated with clinico-pathological parameters and
survival of the patients.
Results: Thirteen percent of all specimens showed
an AI, 35% a LVI and 5% a PNI. The invasion factors
were mostly significantly correlated with the established
prognostic parameter, including bone marrow micrometastases. Kaplan-Meier analysis revealed a prognostic
impact for LVI in both cancer subtypes, while AI and
PNI were significant factors in adenocarcinoma only. In
multivariate analysis, none showed statistical
significance. However, sub-analysis of completely
resected, node negative and non-metastasized patients
showed a significant prognostic impact of LVI.
Conclusion: The prognostic significance of AI, LVI
and PNI seems to be limited compared to the established
prognostic parameters of the UICC staging system. In
completely resected, node negative and nonmetastasized patients, LVI is an independent prognostic
parameter for a worse outcome. Those patients might
benfit from additional treatment or more intensive
follow up.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. CC BY 4.0