Publication: Caspase-3 and caspase-6 in ductal breast carcinoma: a descriptive study
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Date
2006
Authors
Blázquez, S. ; Sirvent, J.J. ; Olona, M. ; Aguilar, C. ; Pelegrí, A. ; Garcia, J.F. ; Palacios, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Caspases are the main point in the apoptotic
process. We have collected some information from 210
cases of Ductal breast cancer (pT1 - pT2) such as tumour
size, histological differentiation degree, lymph node
status and tumor necrosis in the infiltrating component
and we have evaluated the number of apoptotic cells or
bodies by TUNEL technique as well as immunohistochemical
studies to evaluate the expression of
caspase 3 and caspase 6, and proliferation index.
Our results show that lymph node status and cell
atypism are independent prognostic factors for
recurrence and mortality and only tumour size is an
independent prognostic factor for recurrence.
However, the apoptotic index and the immunohistochemical
expression of caspases and cell
proliferation index have not turned out to be independent
prognostic factors neither for recurrence nor mortality.
These results show that classic prognostic factors
known until now are the most important factors to
predict the evolution of the illness.
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