Publication: Factors influencing malignant evolution and long-term
survival in solitary fibrous tumours of the pleura
Authors
Rodríguez-González, Marta ; Nuria M., Novoa ; Gomez, Maria T. ; García, J.L. ; Ludeña, Dolores
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-29.1445
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info:eu-repo/semantics/article
Description
Abstract
Solitary pleuro-pulmonary fibrous tumours
are relatively uncommon neoplasms that are difficult to
manage therapeutically and which, cytogenetically, have
been poorly studied.
The aim of the present work was to analyse the
characteristics of a series of consecutive operated
solitary pleural fibrous tumours in an attempt to discover
a malignant pattern of evolution.
This was a retrospective observational study of 19
cases. Samples were studied for clinical, histological,
immunohistochemical and cytogenetic characteristics
(aCGH, FISH). Descriptive statistics were used: the
Kapplan-Meyer log-rank test and the Cox-regression
model for survival analysis. Analysis of malignant
evolution was achieved using 2x2 tables; significant
factors were included in a binary logistic regression
model.
Parietal pleural implantation of the primary tumour,
high mib1 expression, and low p53 expression were seen
to be statistically significant factors for survival. We
recommend a close follow-up for patients with a
malignant primary tumour and low p53 expression and a
regular long-term follow-up for benign primary tumours
with a high mib1 index, high positive p53, and deletions.
These findings need confirmation in more extensive
series.
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