Publication: Prolonged oval cell proliferation with Ito cell activation and extracellular matrix accumulation in
galactosamine-induced acute hepatitis in mini rats
Authors
Uetsuka, K. ; Suzuki, M. ; Nakayama, Hiroyuki ; Doi, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Histopathological and immunohistochemical
studies were carried out on D-galactosamine (Ga1NAc)-
induced acute hepatitis in rats of the JCl: Wistar TgN
(ARGHGEN) 1 Nts strain (Mini rats), in which
expression of the growth hormone gene is suppressed by
an antisense transgene. Hepatitis characterized by
hepatocellular acidophilic necrosis with inflammatory
cell infiltration was most prominent at 2 days after
GalNAc (1000mglkg)-injection, when proliferation of
Ito cells and deposition of fibronectin and laminin were
found along the sinusoidal linings. At 72 hours after
GalNAc-injection, Ito cell proliferation with deposition
of laminin and fibronectin became more prominent, and
marked proliferation of small epithelial cells was
observed in the periportal area. At 7 days after GalNAcinjection,
quite a number of a-smooth muscle actinpositive
Ito cells, surrounded by abundant fibronectin,
laminin and type IV collagen, were still observed in
close juxtaposition to rapidly proliferating small
epithelial cells. The small epithelial cells were found to
be positive for both a-fetoprotein and cytokeratin 7 and
were therefore considered to be so-called oval cells. The
results suggest that there may be some relation between
oval cell proliferation, Ito cell activation and extracellular
matrix accumulation in GalNAc-induced acute
hepatitis in Mini rats.
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