Publication: Apoptosis in hepatocellular carcinomas with neuroendocrine differentiation
Authors
Zhao, M. ; Zimmermann, Astrid
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We have studied apoptosis in a subset of
thirty hepatocellular carcinomas (HCCs) exhibiting
neuroendocrine differentiation (ND). Apoptosis was
assessed by use of in situ DNA end labelling, and was
quantified employing a TdT labelling index. It turned out
that apoptosis occurred in HCCs with ND, albeit at
different rates. Apoptosis was visualized as a clearly
detectable reaction product mostly localized in tumor
cell nuclei and in apoptotic bodies. Almost no staining
was observed in nuclei of multinuclear tumor giant cells.
In HCCs with ND, apoptosis was not related to type or
grade, but tumors mainly consisting of hepatocyte-like
cells andlor clear cells showed a significantly higher
apoptotic rate. This was also the cell type most
frequently disclosing neuroendocrine features. The
apoptotic rate was significantly higher in HCCs with ND
han in a control group of HCCs not showing ND. The
findings suggest that neuroendocrine differentiation in
liver cell tumors is associated with an aitered pattem of
programmed cell death, and that this phenomenon may
therefore have an influence on clinical behavior.
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