Publication: Proposal of a new disease concept
“biliary diseases with pancreatic counterparts”.
Anatomical and pathological bases
Authors
Nakanuma, Yasuni ; Harada, Kenichi ; Sasaki, Motoko ; Sato, Yasunori
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
y. The biliary tract and pancreas are located
closely anatomically, and both develop from the
endoderm foregut almost at the same time. Interestingly,
the lining epithelia of the bile duct and main pancreatic
duct show similar morphologies and phenotypes, and
both are accompanied by periductal glands. Furthermore,
the exocrine pancreatic acini are remnantly found in the
peribiliary glands. Based on these findings, it seems
plausible that the biliary tract has features of pancreatic
elements in addition to the duct system, which is
specialized for the drainage of bile secreted by hepatic
parenchyma, particularly, hepatocytes. Interestingly,
some pancreatic and biliary diseases show similar
pathological features and even biological behaviors. For
example, extrahepatic cholangiocarcinoma and ductal
adenocarcinoma of the pancreas share many
clinicopathological features. Both of them are
hypothesized to arise from similar preneoplastic and
early neoplastic intraepithelial lesions. Intraductal
papillary tumors, with frequent mucin hyperproduction,
develop in the pancreas (intraductal papillary mucinous
neoplasm) and also in the biliary tract (intraductal
papillary neoplasm of the bile duct). IgG4-related
disease affects the biliary tract (IgG4-related sclerosing
cholangitis) and the pancreas (autoimmune pancreatitis)
in the same patients, with both showing similar
morphologies. Herein, we propose that these nonneoplastic
and neoplastic biliary diseases showing
similarities to corresponding pancreatic diseases could
be included in a new disease concept “biliary diseases
with pancreatic counterparts”. Based on this new
concept, information obtained in biliary tract diseases
could be applied to the analysis of pancreatic disease and
vice versa, and also novel therapeutical strategies and
molecular and genetic studies on pancreatic and biliary
diseases may be developed with a unified approach
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Citation
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