Publication: Clinicopathologic and prognostic significance of
cyclooxygenase-2 expression in endometrial carcinoma
Authors
Lambropoulou, M. ; Alexiadis, G. ; Limberis, V. ; Nikolettos, N. ; Tripsianis, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Backgroud: Endometrial carcinoma is the
most common malignancy of the female genital tract in
the Western world. COX-2 is highly expressed in
endometrial carcinoma, but there is controversy
regarding its clinical role and its possible prognostic
role. COX-2 expression was determined by immunohistochemistry
and was correlated to standard clinicopathologic
variables in a series of primary untreated
endometrial carcinoma patients. COX-2 as an accurate
predictor of the disease was also analyzed. Methods:
One-hundred and ten cases of primary untreated
endometrial carcinoma hosts who were admitted to the
Department of Obstetrics and Gynecology, University
General Hospital of Alexandroupolis, were investigated.
Immunohistochemistry was performed using rabbit
polyclonal antiserum against human COX-2. Results:
Twenty-eight patients (25.5%) were scored as COX-2
positive. A statistically significant association was found
between COX-2 overexpression and FIGO stage
(p=0.010). A positive correlation was also found with
histological grade (p=0.019) and myometrial invasion
(p=0.026). No significant association was found with
histologic type of the tumor (p=0.164). COX-2 positive
patients had a significant association with sort survival
(p=0.028). Conclusions: COX-2 expression is an
independent clinicopathologic factor and an independent
prognostic factor in endometrial carcinoma. It could be
used to plan treatment modalities for hosts.
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