Publication: Regulation of the MAPK family members: Role of subcellular localization and architectural organization
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Date
1999
Authors
Fanger, G.R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The members of the mitogen-activated
protein kinase (MAPK) family are regulated by a diverse
array of extracellular cues ranging from cytokines,
growth factors and neuropeptides, which activate cell
surface receptors, to stresses such as cold, heat, osmolarity
changes and irradiation. The MAPK pathways
control genetic expression by modifying transcription
factor activity and cue important cell fate decisions
including survival, proliferation, and programmed cell
death (apoptosis). One interesting feature of the MAPK
pathways is that the components are evolutionarily
conserved from yeast to human, and many of the
pathways are similarly organized and regulated. Unlike
previously imagined, architectural organization or the
multimeric organization of signaling proteins into
complexes which are localized to distinct subcellular
regions is an important mechanism that influences the
regulation of these pathways. In addition, extracellular
stimuli can induce relocalization of specific signal
transduction proteins. The formation of multimeric
signaling complexes, as well as the dynamic movement
of signaling proteins, contribute to determine signaling
specificity and efficacy. This review describes what is
currently known about the subcellular localization of
MAPK pathway signaling proteins and the relocalization
that occurs during events associated with activation of
the MAPK family members.
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