Publication: Histopathological features of endometritis eosinophilica in mares
Authors
Grimm, Anna Lena ; Schoon, Heinz Adolf ; Schöniger, Sandra
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-872
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info:eu-repo/semantics/article
Description
Abstract
Equine endometritis eosinophilica (EE) is
rarely described and its diagnostic criteria are not
defined. The aim of this study was to characterize
histological features of EE. A data base (1995-2013) was
searched for biopsies with increased eosinophils. This
study included all biopsies with this diagnosis and
representative biopsies without this record. The
definition of equine EE was based on criteria for EE in
women and the results of the determination of
physiological numbers of eosinophils within the equine
endometrium. EE was diagnosed in 55 mares. Biopsies
of 10 mares contained eosinophils exceeding the
physiological range, but no EE; the diagnosis of
eosinophilic infiltrates (EI) was applied. Those of the
remaining mares (n=126) displayed eosinophils within
the physiological range (EWPR). An irregular glandular
differentiation during the breeding season was detected
in 25% of mares with EE, 33% of mares with EI and
24% of the mares with EWPR. Most mares with EE
(93%), EI (90%) and EWPR (72%) showed endometrosis; it was high grade in 11% with EE and 7% with
EWPR. Endometritis was diagnosed within 56% of
mares with EE, 40% of mares with EI and 37% of those
with EWPR. In mares with EE suppurative endometritis
dominated (58%) and in those with EWPR nonsuppurative endometritis (58%). This study indicates EE
as a primary fertility reducing disease. Results suggest
an association between eosinophilic infiltration and the
presence of neutrophils. Further, they provide the basis
for future studies into the pathogenesis, prognosis and
therapy of EE.
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