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PIP5K3 upregulation correlates with unfavorable prognosis in patients with nasopharyngeal carcinoma

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dc.contributor.authorHung-Chang Wu
dc.contributor.authorChing-Chieh Yang
dc.contributor.authorYun-Tzu Lin
dc.contributor.authorChien-Feng Li
dc.contributor.authorShih-Lun Chang
dc.contributor.authorYu-Hsuan Kuo
dc.contributor.authorSzu-Chi Yao
dc.contributor.departmentBiología Celular e Histología
dc.contributor.editorUniversidad de Murcia, Departamento de Biologia Celular e Histiologia
dc.date.accessioned2026-05-07T08:59:18Z
dc.date.available2026-05-07T08:59:18Z
dc.date.issued2026
dc.description.abstractBackground. Nasopharyngeal carcinoma (NPC) is prevalent in East and Southeast Asia, with metastasis and recurrence leading to poor prognosis. Identifying prognostic biomarkers is essential. Methods. We analyzed differentially expressed genes involved in the phosphatidylinositol metabolic process (GO: 0046488) and tumorigenesis (GSE12452) in NPC. Associations between PIP5K3 expression and clinicopathological features were assessed using chi square tests and Cox proportional hazards models. Results. PIP5K3 was significantly upregulated in NPC tissues, correlating with advanced stage (p=0.001) and nodal metastasis (p<0.001). High PIP5K3 expression was associated with worse disease-specific survival (DSS), distant metastasis-free survival (DMeFS), and local recurrence-free survival (LRFS). Multivariate analysis confirmed its association with poor prognosis (DSS: HR=4.321, DMeFS: HR=2.883, LRFS: HR=2.249; all p<0.001). Conclusions. PIP5K3 upregulation is associated with unfavorable clinical outcomes in NPC and may serve as a novel prognostic biomarker and potential therapeutic target.
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dc.format.extent9
dc.identifier.doihttps://doi.org/10.14670/HH-18-996
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/230322
dc.languageeng
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPIP5K3
dc.subjectPhosphatidylinositol metabolism-related genes
dc.subjectNasopharyngeal carcinoma
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titlePIP5K3 upregulation correlates with unfavorable prognosis in patients with nasopharyngeal carcinoma
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology, Vol.41, Nº5, (2026)