Publication: Ultrastructure of pancreatic exocrine cells of the rat during starvation.
Authors
Takashi Kitagawa ; Kazuyuki Ono
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Ultrastructural changes of the pancreatic
exocrine cells after 3, 7, 14, 21, 28, 35 and 42 days
of starvation were observed in male rats aged from
16 to 18 months weighing between 600 and 700 grams.
The number of zymogen granules after starvation
decreased to less than about 70 per cent of that of the
control. Changes in the rough endoplasmic reticulum were
hardly seen up to 14 days of starvation as compared with
the control, but were observed in the apical and basal
cytoplasm of the cell from 21 days after starvation.
Particularly in 35- and 42-day starved rats, the rough
endoplasmic reticulum was frequently shortened and
dilated, and changed to disorganized membranous
structures. The lysosomes in the apical cytoplasm of
the cell gradually increased in number after starvation,
and contact or fusion between the zymogen granules and
lysosomes (viz. so-called crinophagy) was often seen
at 35 and 42 days of starvation. Large autolysosomes
especially those containing zymogen granules and rough
endoplasmic reticulum were also marked in the basal
cytoplasm of the cell after 35 and 42 days of starvation.
Alterations in the basal cytoplasm of the cell appeared
later than those in the apical cytoplasm. It was considered
that, owing to its role in protein synthesis, the basal
cytoplasm of the pancreatic exocrine cells in starved
rats might be protected as far as possible during long-term starvation.
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